Crocin Ds Usage, Dosage, Side Effects, FAQ - Drugs FAQ (2023)

Crocina DsSuspension

Crocin Ds exhibits an analgesic action by peripherally blocking the generation of pain impulses. It produces antipyresis by inhibiting the thermoregulatory center of the hypothalamus. Its weak anti-inflammatory activity is related to the inhibition of prostaglandin synthesis in the CNS.

Crocin Ds (paracetamol) is believed to act primarily in the CNS, increasing the pain threshold by inhibiting both cyclooxygenase isoforms, the COX-1, COX-2 and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and therefore has no peripheral anti-inflammatory effects. Although aspirin acts as an irreversible inhibitor of COX and directly blocks the active site of the enzyme, studies have found that acetaminophen indirectly blocks COX and that this blockade is ineffective in the presence of peroxides. This may explain why paracetamol is effective on the central nervous system and endothelial cells, but not on platelets and immune cells that have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known COX-1 and COX-2 variants. This enzyme is now known as COX-3. Its exact mechanism of action is not yet well understood, but future research may provide more information on how it works. The antipyretic properties of acetaminophen are probably due to direct effects on heat-regulating centers in the hypothalamus, resulting in peripheral vasodilation, sweating, and thus heat dissipation.

usos

Crocin Ds IV is used for the treatment of mild to moderate pain, the treatment of moderate to severe pain with adjunctive opioid analgesics, the reduction of fever.

Crocin Ds is a non-salicylate antipyretic and non-opioid analgesic. Crocin Ds IV Injection is a sterile, clear, colorless, non-pyrogenic isotonic formulation of Crocin Ds intended for intravenous infusion.

Crocin Ds is also used in combination treatment for these conditions: acute gouty arthritis, acute musculoskeletal pain, allergies, ankylosing spondylitis (AS), arthritis, chills, cold, cold symptoms, common cold, common cold/flu, cough, cough caused by common cold, cough caused by influenza caused by influenza, dyskinesia of the biliary tract, dyskinesia of the urinary tract, febrile convulsions, acute febrile illness, fever, fibromyalgia syndrome, influenza caused by influenza, headache, joint dislocations, menstrual discomfort (dysmenorrhea ), Mild pain, Muscle inflammation, Muscle injuries, Muscle spasms, Musculoskeletal pain, Nasal congestion, Neuralgia, Osteoarthritis (OA), Pain, Pollen allergy, Postoperative pain, Premenstrual cramps, Rheumatoid arthritis, Rhinopharyngitis, Rhinorrhoea, Severe pain, Sinusitis , Pain, Muscle, spasms, spastic pain of the gastrointestinal tract, sprains, headache a from tension, toothache, thorium upper respiratory tract infection, whiplash syndrome, acute torticollis, mild moderate pain, mild aches and pains, mild pain, moderate pain, airway clearance therapy, antispasmodic, bronchodilation

Crocina Ds

Structure

Dose

Crocin Ds Dosage

Adults and adolescents weighing 50 kg or more: The recommended dose of Crocin Ds IV is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Crocin Ds IV of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Crocin Ds of 4000 mg per day.

Adults and adolescents weighing less than 50 kg: The recommended dose of Crocin Ds IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Crocin Ds IV of 15 mg/kg, a minimum dosing interval of 4 hours and a maximum daily dose of Crocin Ds of 75 mg/kg per day.

Children >2 to 12 years: The recommended dose of Crocin Ds IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Crocin Ds IV of 15 mg/kg, a minimum dosing interval of 4 hours and a maximum daily dose of Crocin Ds of 75 mg/kg per day.

Collateral damage

As with all acetaminophen products, adverse drug reactions are rare (>1/10,000, <1/1,000) or very rare (<1/10,000). Common injection site adverse reactions (pain and burning sensation) were reported during clinical studies. Very rare cases of hypersensitivity reactions ranging from a simple rash or urticaria to anaphylactic shock have been reported and require discontinuation of treatment. Cases of erythema, flushing, pruritus and tachycardia have been reported.

Caution

Administration of Crocin Ds in doses higher than those recommended may cause liver damage, including the risk of severe hepatotoxicity and death. Do not exceed the maximum recommended daily dose of Crocin Ds. Use caution when administering Crocin Ds to patients with the following conditions: hepatic insufficiency or active liver disease, alcoholism, chronic malnutrition, severe hypovolemia (eg, due to dehydration or blood loss), or severe renal insufficiency (creatinine clearance < 30ml/min). ). There have been rare reports of life-threatening anaphylaxis requiring emergency medical attention. Discontinue Crocin Ds IV immediately if symptoms associated with allergy or hypersensitivity occur. Do not use Crocin Ds IV in patients with an allergy to Crocin Ds.

food interaction

• Avoid alcohol. Alcohol can increase the risk of hepatotoxicity.

Volume of distribution

The volume of distribution is approximately 0.9 l/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol appears to be widely distributed in most body tissues except fat.

Half life

The half-life for adults is 2.5 hours after a 15 mg/kg intravenous dose. After an overdose, the half-life can vary from 4 to 8 hours, depending on the severity of the liver damage, since it metabolizes acetaminophen a lot.

Release

Adults: 0.27 L/h/kg after a 15 mg/kg intravenous (IV) dose. Children: 0.34 L/h/kg after 15 mg/kg IV (IV dose).

Use in pregnancy and lactation

Pregnancy Category C. There are no studies of intravenous Crocin D in pregnant women; however, epidemiological data on oral use of Crocin D in pregnant women do not show an increased risk of major birth defects. Animal reproduction studies have not been conducted with Crocin Ds IV and it is not known whether Crocin Ds IV can cause fetal harm when administered to a pregnant woman. Crocin Ds IV should be given to a pregnant woman only if clearly needed. There are no adequate and well-controlled studies with Crocin Ds IV during labor and delivery; therefore, it should be used in such scenarios only after careful benefit-risk assessment. Although studies with IV Crocin Ds have not been performed, Crocin Ds is secreted into human milk in small amounts after oral administration.

Contraindication

Crocin Ds is contraindicated in patients with a known hypersensitivity to its active ingredient or to any of the excipients in the intravenous formulation. Also contraindicated in patients with severe hepatic impairment or severe active liver disease

special notice

pediatric use: The safety and efficacy of Crocin Ds IV for the treatment of acute pain and fever in pediatric patients 2 years of age and older is supported by evidence from adequate and well-controlled studies of Crocin Ds IV in adults.

geriatric use: No overall differences in safety or efficacy were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between elderly and younger patients.

Patients with liver failure: Crocin Ds is contraindicated in patients with severe hepatic impairment or severe active liver disease and should be used with caution in patients with hepatic impairment or active liver disease. A reduced total daily dose of Crocin Ds may be warranted.

Patients with Renal Failure: In cases of severe renal impairment (creatinine clearance < 30 ml/min), longer dosing intervals and a reduced total daily dose of Crocin Ds may be necessary.

Storage condition

Store in a cool, dry place and out of the reach of children. For a single use. The product must be used within 6 hours of opening. Do not refrigerate or freeze.