Crocin Ds Usage, Dosage, Side Effects, FAQ - Drugs FAQ (2023)

Crocina DsSuspension

Crocin Ds exhibits an analgesic action by peripherally blocking the generation of pain impulses. It produces antipyresis by inhibiting the thermoregulatory center of the hypothalamus. Its weak anti-inflammatory activity is related to the inhibition of prostaglandin synthesis in the CNS.

Crocin Ds (paracetamol) is believed to act primarily in the CNS, increasing the pain threshold by inhibiting both cyclooxygenase isoforms, the COX-1, COX-2 and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and therefore has no peripheral anti-inflammatory effects. Although aspirin acts as an irreversible inhibitor of COX and directly blocks the active site of the enzyme, studies have found that acetaminophen indirectly blocks COX and that this blockade is ineffective in the presence of peroxides. This may explain why paracetamol is effective on the central nervous system and endothelial cells, but not on platelets and immune cells that have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known COX-1 and COX-2 variants. This enzyme is now known as COX-3. Its exact mechanism of action is not yet well understood, but future research may provide more information on how it works. The antipyretic properties of acetaminophen are probably due to direct effects on heat-regulating centers in the hypothalamus, resulting in peripheral vasodilation, sweating, and thus heat dissipation.


Crocin Ds IV is used for the treatment of mild to moderate pain, the treatment of moderate to severe pain with adjunctive opioid analgesics, the reduction of fever.

Crocin Ds is a non-salicylate antipyretic and non-opioid analgesic. Crocin Ds IV Injection is a sterile, clear, colorless, non-pyrogenic isotonic formulation of Crocin Ds intended for intravenous infusion.

Crocin Ds is also used in combination treatment for these conditions: acute gouty arthritis, acute musculoskeletal pain, allergies, ankylosing spondylitis (AS), arthritis, chills, cold, cold symptoms, common cold, common cold/flu, cough, cough caused by common cold, cough caused by influenza caused by influenza, dyskinesia of the biliary tract, dyskinesia of the urinary tract, febrile convulsions, acute febrile illness, fever, fibromyalgia syndrome, influenza caused by influenza, headache, joint dislocations, menstrual discomfort (dysmenorrhea ), Mild pain, Muscle inflammation, Muscle injuries, Muscle spasms, Musculoskeletal pain, Nasal congestion, Neuralgia, Osteoarthritis (OA), Pain, Pollen allergy, Postoperative pain, Premenstrual cramps, Rheumatoid arthritis, Rhinopharyngitis, Rhinorrhoea, Severe pain, Sinusitis , Pain, Muscle, spasms, spastic pain of the gastrointestinal tract, sprains, headache a from tension, toothache, thorium upper respiratory tract infection, whiplash syndrome, acute torticollis, mild moderate pain, mild aches and pains, mild pain, moderate pain, airway clearance therapy, antispasmodic, bronchodilation

Crocina Ds

Tradename Crocina Ds
Generic Paracetamol
Other names for paracetamol Acenol, Acetaminofeno, Acetaminofeno, Acetaminofeno, APAP, Paracetamol, Paracetamol, Paracetamol
Type Suspension
Formula C8H9NO2
Weight Average: 151.1626
Monoisotope: 151.063328537
protein bond

Paracetamol binding to plasma proteins is low (between 10% and 25%) when administered in therapeutic doses.

therapeutic class non-opioid pain relievers
Manufacturer Glaxosmithkline
available country India
Last update: June 7, 2022 at 8:53 p.m.


Crocin Ds Usage, Dosage, Side Effects, FAQ - Drugs FAQ (1)


  • Crocina Ds
  • usos
  • Dose
  • Side effect
  • Precautions
  • interactions
  • Uses during pregnancy
  • Uses during lactation
  • precise overdose
  • food interaction
  • Half life
  • Volume of distribution
  • Release
  • Interaction with another drug
  • Contradiction
  • Store


Crocin Ds Dosage

Adults and adolescents weighing 50 kg or more: The recommended dose of Crocin Ds IV is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Crocin Ds IV of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Crocin Ds of 4000 mg per day.

Adults and adolescents weighing less than 50 kg: The recommended dose of Crocin Ds IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Crocin Ds IV of 15 mg/kg, a minimum dosing interval of 4 hours and a maximum daily dose of Crocin Ds of 75 mg/kg per day.

Children >2 to 12 years: The recommended dose of Crocin Ds IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Crocin Ds IV of 15 mg/kg, a minimum dosing interval of 4 hours and a maximum daily dose of Crocin Ds of 75 mg/kg per day.

Collateral damage

As with all acetaminophen products, adverse drug reactions are rare (>1/10,000, <1/1,000) or very rare (<1/10,000). Common injection site adverse reactions (pain and burning sensation) were reported during clinical studies. Very rare cases of hypersensitivity reactions ranging from a simple rash or urticaria to anaphylactic shock have been reported and require discontinuation of treatment. Cases of erythema, flushing, pruritus and tachycardia have been reported.


Administration of Crocin Ds in doses higher than those recommended may cause liver damage, including the risk of severe hepatotoxicity and death. Do not exceed the maximum recommended daily dose of Crocin Ds. Use caution when administering Crocin Ds to patients with the following conditions: hepatic insufficiency or active liver disease, alcoholism, chronic malnutrition, severe hypovolemia (eg, due to dehydration or blood loss), or severe renal insufficiency (creatinine clearance < 30ml/min). ). There have been rare reports of life-threatening anaphylaxis requiring emergency medical attention. Discontinue Crocin Ds IV immediately if symptoms associated with allergy or hypersensitivity occur. Do not use Crocin Ds IV in patients with an allergy to Crocin Ds.

food interaction

  • Avoid alcohol. Alcohol can increase the risk of hepatotoxicity.

Volume of distribution

The volume of distribution is approximately 0.9 l/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol appears to be widely distributed in most body tissues except fat.

Half life

The half-life for adults is 2.5 hours after a 15 mg/kg intravenous dose. After an overdose, the half-life can vary from 4 to 8 hours, depending on the severity of the liver damage, since it metabolizes acetaminophen a lot.


Adults: 0.27 L/h/kg after a 15 mg/kg intravenous (IV) dose. Children: 0.34 L/h/kg after 15 mg/kg IV (IV dose).

Use in pregnancy and lactation

Pregnancy Category C. There are no studies of intravenous Crocin D in pregnant women; however, epidemiological data on oral use of Crocin D in pregnant women do not show an increased risk of major birth defects. Animal reproduction studies have not been conducted with Crocin Ds IV and it is not known whether Crocin Ds IV can cause fetal harm when administered to a pregnant woman. Crocin Ds IV should be given to a pregnant woman only if clearly needed. There are no adequate and well-controlled studies with Crocin Ds IV during labor and delivery; therefore, it should be used in such scenarios only after careful benefit-risk assessment. Although studies with IV Crocin Ds have not been performed, Crocin Ds is secreted into human milk in small amounts after oral administration.


Crocin Ds is contraindicated in patients with a known hypersensitivity to its active ingredient or to any of the excipients in the intravenous formulation. Also contraindicated in patients with severe hepatic impairment or severe active liver disease

special notice

pediatric use: The safety and efficacy of Crocin Ds IV for the treatment of acute pain and fever in pediatric patients 2 years of age and older is supported by evidence from adequate and well-controlled studies of Crocin Ds IV in adults.

geriatric use: No overall differences in safety or efficacy were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between elderly and younger patients.

Patients with liver failure: Crocin Ds is contraindicated in patients with severe hepatic impairment or severe active liver disease and should be used with caution in patients with hepatic impairment or active liver disease. A reduced total daily dose of Crocin Ds may be warranted.

Patients with Renal Failure: In cases of severe renal impairment (creatinine clearance < 30 ml/min), longer dosing intervals and a reduced total daily dose of Crocin Ds may be necessary.

Storage condition

Store in a cool, dry place and out of the reach of children. For a single use. The product must be used within 6 hours of opening. Do not refrigerate or freeze.

Frequent questions

What is Crocin Ds?

Crocin Ds is a common pain reliever used to treat pain. It can also be used to reduce a high temperature. It is available in combination with other pain relievers and anti-disease drugs. It is also an ingredient in a wide range of cold and flu remedies.

What are the side effects of Crocin Ds?

  • Skin rash that may include itching, redness, swelling, blistering, or peeling skin.
  • wheezing
  • Tightness in the chest or throat.
  • Difficulty breathing or speaking.
  • The mouth, face, lips, tongue, or throat begin to swell.

How safe is Crocin Ds?

Crocin Ds is known to cause liver failure in overdose, but it also causes liver failure in people taking standard doses for pain relief. The risk is only one in a million, but it is a risk. All of these different risks add up.

What are the types of Crocin Ds?

Types of Crocin Ds

  • pills or capsules.
  • capsules
  • liquid – usually for children.
  • soluble tablets (tablets that dissolve in water to make a drink)
  • suppositories (capsules inserted into the back passage)
  • an injection given into a vein, usually only used in hospitals.

What happens if I take Crocin Ds for no reason?

Even taking one or two more pills than recommended can cause serious liver damage and possibly death. Crocin D overdose is one of the main causes of liver failure.

Why Crocin Ds is bad for our liver?

Crocin Ds itself is non-toxic, but in large amounts it exceeds the body's ability to safely process it. This can lead to the buildup of a toxic metabolite (or breakdown product) that binds to liver cells and causes those cells to die.

What are the indications of Crocin Ds?

This Crocin Ds is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, back pain, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

What happens if I take Crocin Ds on an empty stomach?

Ibuprofen, aspirin, and other NSAIDs (non-steroidal anti-inflammatory drugs) can irritate the stomach lining, so it's best to take them with food or a glass of milk. Crocin Ds does not irritate the stomach lining, so it does not matter if you have not eaten.

Can Crocin Ds Help You Sleep?

A successful outcome is one in which the pain is reduced by half or more, or in which there is no pain or only mild pain. This result not only provides pain but also improves sleep, depression, quality of life, work, and the ability to get on with life.

How is Crocin Ds removed from the body?

Crocin Ds is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring approximately 30 minutes to 2 hours after ingestion. It is metabolized in the liver (90-95%) and excreted in the urine mainly in the form of glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged Crocin Ds.

Is Crocin Ds Safe During Pregnancy?

Crocin Ds is the first choice pain reliever if you are pregnant. Many pregnant women have taken Crocin D with no ill effects to mother or baby.

Is Crocin Ds safe while breastfeeding?

Crocin Ds is the first choice for pain reliever if you are breastfeeding. It has been taken by many breastfeeding women with no ill effects to mother or baby.

How does Crocin D's work?

Crocin Ds seems to work by blocking chemical messengers in the brain that tell us we are in pain. It also reduces fever by affecting chemical messengers in an area of ​​the brain that regulates body temperature.

When will I feel better after taking Crocin Ds?

Crocin Ds takes up to an hour to take effect. It keeps working for about 5 hours.

Can I take Crocin Ds for a long time?

It is safe to take Crocin Ds regularly for many years as long as you do not take more than the recommended dose.

Will Crocin Ds affect my fertility?

There is no firm evidence to suggest that taking Crocin Ds reduces fertility in men or women.

Will Crocin D affect my birth control?

Crocin Ds does not affect any form of contraception, including the birth control pill or emergency contraception.

Can I drink alcohol with Crocin Ds?

Drinking a small amount of alcohol while taking Crocin Ds is generally safe. Try to stick to the recommended guidelines of no more than 14 units of alcohol per week. A standard wine glass (175ml) is 2 units. A pint of lager or beer usually has 2-3 units of alcohol.

Are there any foods or drinks that I should avoid while taking Crocin Ds?

You can eat and drink normally while taking Crocin Ds. You can safely take Crocin Ds (but not ibuprofen) on an empty stomach.

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